Table 4 Data set displaying the pharmacophore feature of COX 2 inhibitor drugs along with Mangiferin
From: In-silico and in-vitro studies on the efficacy of mangiferin against colorectal cancer
Molecule | Atoms | Features | Spatial features | Aromatic | Hydrophobic | Donors | Acceptors | Negative | Positive |
|---|---|---|---|---|---|---|---|---|---|
Bextra | 36 | 15 | 14 | 2 | 7 | 1 | 5 | 0 | 0 |
Celebrex | 40 | 17 | 16 | 1 | 10 | 1 | 4 | 0 | 1 |
Nimesulide | 33 | 9 | 9 | 2 | 1 | 1 | 5 | 0 | 0 |
Indomethacin | 40 | 12 | 12 | 2 | 4 | 0 | 4 | 1 | 1 |
Vioxx | 36 | 8 | 8 | 2 | 2 | 0 | 4 | 0 | 0 |
Mangiferin | 48 | 22 | 14 | 3 | 0 | 8 | 11 | 0 | 0 |