In-silico and in-vitro studies on the efficacy of mangiferin against colorectal cancer

BMC Chemistry

Table 1 Docking results for the Mangiferin-protein interaction

Sl. No.	Protein receptors	PDB ID	Binding energy (kcal/mol)
1	APC	3NMZ	−8
2	BUBR1	3SI5	−6.7
3	CDK8	3RGF	−8.1
4	CK2α	3WAR	−8.3
5	FABP6	5L8I	−8.8
6	K-Ras	4OBE	−8.6
7	Spindle assembly checkpoint protein human MAD2	1DUJ	−7.6
8	Bcl-xL	1MAZ	−7.4
9	Bcl-2	2XA0	−7.6
10	COX-2	3NT1	−10.1
11	CYTOCHROME P450	4NZ2	−8.7
12	PROTEIN KINASE B	1UNR	−7.7
13	TNFα	4TWT	−7.6
14	LEUKOTRIENE A4 HYDROLASE	1HS6	−10.3
15	NF-қB	1VKX	−8.2

ISSN: 2661-801X