Scheme 1

Synthesis of 2-(5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-ylimino)thiazolidin-4-one derivatives 7–31. Reagents and conditions: a) Thiosemicarbazide, Ethanol, Hydrochloric Acid, Reflux, 1.5 h, b) Ferric Ammonium Sulfate, Water, Reflux 24 h, c) Chloroacetyl Chloride, Toluene, 80–90 °C, 3 h, d) Ammonium thiocyanate, Ethanol, reflux, 3 h, e) ArCHO, Sodium Acetate, Acetic Acid, Reflux, 24 h