From: Design, synthesis, and bioactivity of ferulic acid derivatives containing an β-amino alcohol
Compd | Xoo | Xac | ||
---|---|---|---|---|
Inhibition rate (%) | Inhibition rate (%) | |||
100 μg/mL | 50 μg/mL | 100 μg/mL | 50 μg/mL | |
D1 | 26.5 ± 1.9 | 21.8 ± 1.2 | 47.4 ± 1.9 | 32.1 ± 1.8 |
D2 | 35.6 ± 2.1 | 31.8 ± 3.8 | 55.3 ± 0.5 | 45.9 ± 3.3 |
D3 | 77.8 ± 2.8 | 66.4 ± 2.7 | 68.2 ± 2.7 | 48.7 ± 1.9 |
D4 | 28.2 ± 2.7 | 28.0 ± 1.1 | 25.2 ± 0.2 | 15.7 ± 2.6 |
D5 | 72.0 ± 1.3 | 55.0 ± 1.2 | 22.5 ± 3.7 | 21.4 ± 0.9 |
D6 | 35.2 ± 0.9 | 17.1 ± 3.0 | 29.7 ± 4.5 | 22.4 ± 4.7 |
D7 | 66.5 ± 1.8 | 47.9 ± 1.0 | 74.5 ± 2.3 | 60.0 ± 2.5 |
D8 | 25.3 ± 1.8 | 19.9 ± 2.2 | 31.9 ± 3.5 | 27.8 ± 2.6 |
D9 | 47.4 ± 1.3 | 32.8 ± 2.9 | 36.2 ± 2.2 | 12.0 ± 4.8 |
D10 | 26.8 ± 3.6 | 23.6 ± 2.7 | 33.1 ± 2.6 | 29.9 ± 0.1 |
D11 | 33.0 ± 1.2 | 32.4 ± 3.6 | 68.5 ± 3.5 | 45.3 ± 1.8 |
D12 | 22.7 ± 1.8 | 22.6 ± 3.7 | 33.5 ± 1.0 | 33.0 ± 0.7 |
D13 | 34.5 ± 2.4 | 26.8 ± 1.3 | 28.6 ± 1.9 | 15.4 ± 3.1 |
D14 | 36.7 ± 4.4 | 22.9 ± 1.1 | 26.7 ± 4.0 | 12.6 ± 3.3 |
D15 | 43.4 ± 2.9 | 26.4 ± 4.0 | 57.9 ± 3.2 | 45.9 ± 1.9 |
D16 | 42.2 ± 0.6 | 26.4 ± 3.1 | 31.1 ± 3.9 | 19.8 ± 4.2 |
D17 | 20.6 ± 1.8 | 8.7 ± 2.8 | 28.2 ± 3.8 | 12.8 ± 2.6 |
D18 | 32.9 ± 2.1 | 30.0 ± 0.8 | 27.7 ± 4.1 | 26.3 ± 2.4 |
D19 | 24.9 ± 3.5 | 19.8 ± 2.0 | 25.1 ± 1.3 | 14.2 ± 4.3 |
D20 | 34.2 ± 0.6 | 5.2 ± 2.2 | 34.4 ± 1.6 | 20.9 ± 0.1 |
D21 | 38.6 ± 2.6 | 37.7 ± 1.8 | 26.0 ± 3.0 | 21.6 ± 3.0 |
D22 | 89.1 ± 3.7 | 68.0 ± 3.1 | 35.7 ± 3.5 | 24.7 ± 2.5 |
D23 | 79.9 ± 1.0 | 63.6 ± 3.6 | 28.5 ± 2.2 | 23.1 ± 3.5 |
D24 | 90.7 ± 0.8 | 80.5 ± 2.7 | 25.9 ± 1.8 | 21.7 ± 3.7 |
BTa | 90.1 ± 2.3 | 80.2 ± 1.3 | 64.6 ± 1.9 | 51.2 ± 1.4 |
TCa | 65.7 ± 0.9 | 46.9 ± 2.6 | 76.8 ± 0.7 | 65.2 ± 2.0 |