Table 2 Synthesis of THDPP’s (5a–m) in water in room temperature
Entry | R | Product | Time (min) | Yield (%)b | M.P (°C) | Lit. M.P. (C) [Reference] |
|---|---|---|---|---|---|---|
1 | 4-Cl | 5a | 45 | 98 | 244–246 | 254–256 [19] |
2 | 4-NO2 | 5b | 60 | 96 | 274–276 | 278–283 [19] |
3 | 3-NO2 | 5c | 50 | 98 | 268–270 | 282–284 [20] |
4 | 4-OH | 5d | 80 | 96 | 266–268 | 267–268 [21] |
5 | 4-Br | 5e | 75 | 96 | 222–224 | 221–224 [19] |
6 | 2-Cl | 5f | 105 | 94 | 162–164 | 164–165 [22] |
7 | 4-N(CH3)2 | 5g | 90 | 85 | 238–239 | 240–242 [19] |
8 | 4-Me | 5h | 180 | 95 | 240–242 | 241–243 [20] |
9 | 4-F | 5i | 75 | 97 | 255–257 | 258–260 [18] |
10 | 4-OCH3 | 5j | 90 | 98 | 187–189 | 188–190 [20] |
11 | 3-OMe-4-OH | 5k | 90 | 98 | 256–258 | 256–258 [20] |
12 | 3,4-(OH)2 | 5l | 90 | 83 | 208–210 | 208–210 [20] |
13 | 4-CHO | 5 m | 120 | 91 | > 300° | > 300° [23] |