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Table 1 Antimicrobial activity (MIC, MBC and MFC in µg/mL) of synthesized compounds as well as reference antimicrobial drugs

From: Synthesis, characterization and antimicrobial properties of two derivatives of pyrrolidine-2,5-dione fused at positions-3,4 to a dibenzobarrelene backbone

Compounds

Inhibition parameters

S. aureus

V. cholerae NB2

V. cholerae SG24

V

cholerae CO6

C. albicans ATCC10231

C. tropicalis PK233

C. neoformans H99

8

MIC

16

64

32

64

256

128

64

 

MBC or MFC

32

128

64

> 256

> 256

> 256

128

 

MBC or MFC /MIC

2

2

2

/

/

/

2

5

MIC

32

64

64

128

128

64

64

 

MBC or MFC

32

128

128

> 256

> 256

> 256

> 256

 

MBC or MFC /MIC

1

2

2

/

/

/

/

3

MIC

64

64

64

128

128

128

128

 

MBC or MFC

128

128

128

> 256

> 256

256

256

 

MBC or MFC /MIC

2

2

2

/

/

2

2

Reference drugs*

MIC

0.50

16

8

16

2

0.50

1

MBC or MFC

0.50

16

8

16

2

0.50

1

MBC or MFC /MIC

1

1

1

1

1

1

1

  1. / not determined, MIC Minimum Inhibitory Concentration, MBC Minimum Bactericidal Concentration, MFC Minimum Fungicidal Concentration
  2. *Nystatin for yeasts and ciprofloxacin for bacteria were tested together with compounds 3, 5 and 8
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BMC Chemistry

ISSN: 2661-801X

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