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Table 1 Antimicrobial activity (MIC, MBC and MFC in µg/mL) of synthesized compounds as well as reference antimicrobial drugs

From: Synthesis, characterization and antimicrobial properties of two derivatives of pyrrolidine-2,5-dione fused at positions-3,4 to a dibenzobarrelene backbone

Compounds Inhibition parameters S. aureus V. cholerae NB2 V. cholerae SG24 V
cholerae CO6
C. albicans ATCC10231 C. tropicalis PK233 C. neoformans H99
8 MIC 16 64 32 64 256 128 64
  MBC or MFC 32 128 64 > 256 > 256 > 256 128
  MBC or MFC /MIC 2 2 2 / / / 2
5 MIC 32 64 64 128 128 64 64
  MBC or MFC 32 128 128 > 256 > 256 > 256 > 256
  MBC or MFC /MIC 1 2 2 / / / /
3 MIC 64 64 64 128 128 128 128
  MBC or MFC 128 128 128 > 256 > 256 256 256
  MBC or MFC /MIC 2 2 2 / / 2 2
Reference drugs* MIC 0.50 16 8 16 2 0.50 1
MBC or MFC 0.50 16 8 16 2 0.50 1
MBC or MFC /MIC 1 1 1 1 1 1 1
  1. / not determined, MIC Minimum Inhibitory Concentration, MBC Minimum Bactericidal Concentration, MFC Minimum Fungicidal Concentration
  2. *Nystatin for yeasts and ciprofloxacin for bacteria were tested together with compounds 3, 5 and 8