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Table 2 MAO inhibitory activity of piperine derivatives

From: Natural based piperine derivatives as potent monoamine oxidase inhibitors: an in silico ADMET analysis and molecular docking studies

Sr. nohMAO-A IC50, µMahMAO-B IC50, µMaDocking score hMAO-AFree energy of binding, kcal/mol (hMAO-A)Docking score hMAO-BFree energy of binding, kcal/mol (hMAO-B)Selectivity indexb
560.19 ± 0.08714.19 ± 0.007− 2.34− 13.4− 10.56− 56.94.241
715.38 ± 0.07152.20 ± 0.006− 9.72− 46.9− 3.24− 11.70.294
922.19 ± 0.0771.01 ± 0.005− 8.76− 32.1− 1.24− 3.20.312
1133.72 ± 0.07120.59 ± 0.006− 5.76− 16.9− 3.89− 14.51.637
1324.53 ± 0.00265.99 ± 0.002− 6.87− 15.8− 2.43− 13.60.371
1530.87 ± 0.00512.15 ± 0.003− 5.67− 16.4− 11.76− 59.52.540
17a32.33 ± 0.04321.37 ± 0.007− 4.84− 12.9− 8.65− 33.21.512
17b30.00 ± 0.00517.90 ± 0.038− 6.32− 15.2− 8.65− 32.81.675
17c16.11 ± 0.09126.44 ± 0.063− 7.98− 16.2− 5.43− 17.30.609
Piperine19.01 ± 0.03117.57 ± 0.037− 5.56− 15.6− 9.4439.51.081
Clorgyline18.74 ± 0.096− 5.773− 16.5
Harmine23.12 ± 0.041− 4.211− 11.9
Pargyline20.04 ± 0.095− 6.061− 15.3
Safinamide24.23 ± 0.011− 5.760− 16.0
  1. aValues related for the evaluated compound absorption which provide 50% MAO-A and MAO-B inhibition, action, and are the mean SEM; statistical significance: p < 0.05 against the equivalent IC50 values achieved against MAO-A and MAO-B, as identified through ANOVA/Dunnett’s test
  2. bSelectivity index = IC50 (MAO-A)/IC50 (MAO-B)