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Table 4 Calculated IC50 values for the tested four NADES solvents and the extractss from S. scardica and P. major

From: Extracts of medicinal plants with natural deep eutectic solvents: enhanced antimicrobial activity and low genotoxicity

Tested samples Median inhibitory concentrations, parameters of the model and exposure time
24 h 72 h
IC50a (% v/v, μl) 95% CIb R IC50 (% v/v, μl) 95% CI Rc
Solvents
 XXGly 1.180 0.985–1.412 0.904 1.394 1.261–1.542 0.950
 CAPD 0.089 0.075–0.105 0.940 0.141 0.126–0.158 0.971
 XXGIH 0.077 0.043–0.139 0.980 0.096 0.085–0.108 0.964
 XXPD 2.677 1.516–4.611 0.906 1.503 1.197–1.887 0.707
Extracts
 XXGly/S 0.803 0.563–1.148 0.952 0.589 0.391–0.886 0.901
 XXGly/P 1.267 0.957–1.679 0.912 1.094 0.845–1.418 0.894
 CAPD/S 0.046 0.040–0.054 0.955 0.148 0.136–0.161 0.971
CAPD/P 0.045 0.039–0.053 0.956 0.024 0.021–0.027 0.962
  IC50 (µg/ml tPd) 95% CI R IC50 (µg/ml tP) 95% CI R
Extracts
 XXGly/S 12.212 8.550–17.450 0.952 8.953 5.941–13.490 0.901
 XXGly/P 15.711 11.863–20.820 0.912 13.566 10.470–17.590 0.894
 CAPD/S 0.046 0.040–0.054 0.955 0.148 0.136–0.161 0.971
 CAPD/P 4.607 4.026–5.376 0.956 0.243 0.210–0.275 0.962
  1. aIC50: inhibitory concentration that inhibits the cell growth by 50%
  2. bCI: confidence interval
  3. cR: coefficient of correlation
  4. dtP: total phenolics