Extracts of medicinal plants with natural deep eutectic solvents: enhanced antimicrobial activity and low genotoxicity

Table 4 Calculated IC₅₀ values for the tested four NADES solvents and the extractss from S. scardica and P. major

Tested samples	Median inhibitory concentrations, parameters of the model and exposure time
	24 h			72 h
	IC₅₀^a (% v/v, μl)	95% CI^b	R	IC₅₀ (% v/v, μl)	95% CI	R^c
Solvents
XXGly	1.180	0.985–1.412	0.904	1.394	1.261–1.542	0.950
CAPD	0.089	0.075–0.105	0.940	0.141	0.126–0.158	0.971
XXGIH	0.077	0.043–0.139	0.980	0.096	0.085–0.108	0.964
XXPD	2.677	1.516–4.611	0.906	1.503	1.197–1.887	0.707
Extracts
XXGly/S	0.803	0.563–1.148	0.952	0.589	0.391–0.886	0.901
XXGly/P	1.267	0.957–1.679	0.912	1.094	0.845–1.418	0.894
CAPD/S	0.046	0.040–0.054	0.955	0.148	0.136–0.161	0.971
CAPD/P	0.045	0.039–0.053	0.956	0.024	0.021–0.027	0.962

	IC₅₀ (µg/ml tP^d)	95% CI	R	IC₅₀ (µg/ml tP)	95% CI	R
Extracts
XXGly/S	12.212	8.550–17.450	0.952	8.953	5.941–13.490	0.901
XXGly/P	15.711	11.863–20.820	0.912	13.566	10.470–17.590	0.894
CAPD/S	0.046	0.040–0.054	0.955	0.148	0.136–0.161	0.971
CAPD/P	4.607	4.026–5.376	0.956	0.243	0.210–0.275	0.962

ISSN: 2661-801X