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Table 22 HIV inhibition activities (reverse transcriptase inhibitor) with therapeutic index [60]

From: Therapeutic potential of oxadiazole or furadiazole containing compounds

Compound EC50 (μM) IC50 (μM) Therapeutic index
45 3.24. 10–3 1.88 2.88. 10–7
47a 1.1. 10–5 12.89 66.24. 10–8
47b 5.26. 10–4 1.44 3.15. 10–7
48a 5.23. 10–4 12.44 5.78. 10–6
48b 1.56. 10–3 3.11 3.45. 10–6
49a 3.81. 10–3 2.12 8.14. 10–6
52 2.72. 10–3 2.9 5.12. 10–6