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Table 20 Antiviral activity of the titled compounds [25]

From: Therapeutic potential of oxadiazole or furadiazole containing compounds

Compound R1 R2 Curative activity(%) Protective activity(%) Inactivation activity(%)
37a 4-F 4-F 43.2 ± 2.1 55.9 ± 1.7 84.4 ± 1.2
37b 4-F 4-Cl 25.9 ± 1.8 52.5 ± 1.5 88.4 ± 0.8
37c 4-F 4-Br 45.6 ± 1.9 67.9 ± 3.9 74.8 ± 1.3
37d 4-F 2-F 31.1 ± 2.3 68.4 ± 3.2 83.4 ± 1.6
37e 4-F 2-Cl 23.7 ± 3.1 56.8 ± 2.6 56.2 ± 1.9
37f 4-F 2,4-Di-Cl 52.9 ± 4.5 65.1 ± 3.2 83.5 ± 2.7
37g 4-F H 28.2 ± 1.1 52.9 ± 0.7 74.5 ± 0.9
37h 4-F 4-CH3 19.2 ± 0.9 60.5 ± 1.1 61.3 ± 0.8
37i 4-F 4-OCH3 27.5 ± 2.1 50.0 ± 1.5 61.4 ± 1.0
37j 4-F 2-CF3 28.3 ± 2.3 47.5 ± 2.4 60.2 ± 1.7
38a H 4-F 45.8 ± 1.8 61.5 ± 2.9 69.1 ± 1.2
38b H 4-Cl 44.1 ± 2.5 55.7 ± 1.6 59.4 ± 2.5
38c H 4-Br 47.2 ± 3.6 53.8 ± 3.9 83.1 ± 2.4
38d H 2-F 38.1 ± 2.6 66.3 ± 1.9 70.1 ± 2.0
38e H 2-Cl 41.1 ± 4.2 61.5 ± 3.1 75.6 ± 2.1
38f H 2,4-Di-Cl 49.8 ± 3.9 69.2 ± 2.1 90.4 ± 2.8
38g H H 20.9 ± 2.1 66.7 ± 2.8 78.0 ± 2.5
38h H 4-CH3 48.1 ± 3.6 57.5 ± 2.7 72.7 ± 3.3
38i H 4-OCH3 40.6 ± 3.2 58.4 ± 3.8 79.3 ± 4.1
38j H 2-CF3 35.5 ± 1.7 50.5 ± 1.9 56.8 ± 2.1
39a 4-OCH3 4-F 20.8 ± 1.2 44.0 ± 0.9 83.0 ± 1.1
39b 4- OCH3 4-Cl 18.4 ± 0.9 34.4 ± 1.1 87.1 ± 1.8
39c 4- OCH3 4-Br 34.8 ± 2.1 41.1 ± 3.6 82.3 ± 5.1
39d 4- OCH3 2-F 25.4 ± 1.7 35.8 ± 1.4 81.3 ± 2.1
39e 4- OCH3 2-Cl 43.5 ± 2.2 46.1 ± 2.6 77.7 ± 2.0
39f 4- OCH3 2,4-Di-Cl 43.9 ± 2.4 49.6 ± 1.8 85.6 ± 1.9
39g 4- OCH3 H 37.8 ± 1.6 42.5 ± 2.0 78.8 ± 2.1
39h 4- OCH3 4-CH3 26.5 ± 1.2 42.1 ± 2.1 86.3 ± 5.4
39i 4- OCH3 4-OCH3 35.1 ± 1.5 41.5 ± 1.8 81.5 ± 2.6
39j 4- OCH3 2-CF3 30.5 ± 2.1 49.3 ± 2.3 77.9 ± 4.5
38k H 2,4-Di-F 55.4 ± 2.8 71.3 ± 1.9 85.2 ± 4.0
Ribavirin    37.9 ± 1.9 51.8 ± 2.3 72.9 ± 2.4