Table 20 Antiviral activity of the titled compounds [25]
From: Therapeutic potential of oxadiazole or furadiazole containing compounds
Compound | R1 | R2 | Curative activity(%) | Protective activity(%) | Inactivation activity(%) |
|---|---|---|---|---|---|
37a | 4-F | 4-F | 43.2 ± 2.1 | 55.9 ± 1.7 | 84.4 ± 1.2 |
37b | 4-F | 4-Cl | 25.9 ± 1.8 | 52.5 ± 1.5 | 88.4 ± 0.8 |
37c | 4-F | 4-Br | 45.6 ± 1.9 | 67.9 ± 3.9 | 74.8 ± 1.3 |
37d | 4-F | 2-F | 31.1 ± 2.3 | 68.4 ± 3.2 | 83.4 ± 1.6 |
37e | 4-F | 2-Cl | 23.7 ± 3.1 | 56.8 ± 2.6 | 56.2 ± 1.9 |
37f | 4-F | 2,4-Di-Cl | 52.9 ± 4.5 | 65.1 ± 3.2 | 83.5 ± 2.7 |
37g | 4-F | H | 28.2 ± 1.1 | 52.9 ± 0.7 | 74.5 ± 0.9 |
37h | 4-F | 4-CH3 | 19.2 ± 0.9 | 60.5 ± 1.1 | 61.3 ± 0.8 |
37i | 4-F | 4-OCH3 | 27.5 ± 2.1 | 50.0 ± 1.5 | 61.4 ± 1.0 |
37j | 4-F | 2-CF3 | 28.3 ± 2.3 | 47.5 ± 2.4 | 60.2 ± 1.7 |
38a | H | 4-F | 45.8 ± 1.8 | 61.5 ± 2.9 | 69.1 ± 1.2 |
38b | H | 4-Cl | 44.1 ± 2.5 | 55.7 ± 1.6 | 59.4 ± 2.5 |
38c | H | 4-Br | 47.2 ± 3.6 | 53.8 ± 3.9 | 83.1 ± 2.4 |
38d | H | 2-F | 38.1 ± 2.6 | 66.3 ± 1.9 | 70.1 ± 2.0 |
38e | H | 2-Cl | 41.1 ± 4.2 | 61.5 ± 3.1 | 75.6 ± 2.1 |
38f | H | 2,4-Di-Cl | 49.8 ± 3.9 | 69.2 ± 2.1 | 90.4 ± 2.8 |
38g | H | H | 20.9 ± 2.1 | 66.7 ± 2.8 | 78.0 ± 2.5 |
38h | H | 4-CH3 | 48.1 ± 3.6 | 57.5 ± 2.7 | 72.7 ± 3.3 |
38i | H | 4-OCH3 | 40.6 ± 3.2 | 58.4 ± 3.8 | 79.3 ± 4.1 |
38j | H | 2-CF3 | 35.5 ± 1.7 | 50.5 ± 1.9 | 56.8 ± 2.1 |
39a | 4-OCH3 | 4-F | 20.8 ± 1.2 | 44.0 ± 0.9 | 83.0 ± 1.1 |
39b | 4- OCH3 | 4-Cl | 18.4 ± 0.9 | 34.4 ± 1.1 | 87.1 ± 1.8 |
39c | 4- OCH3 | 4-Br | 34.8 ± 2.1 | 41.1 ± 3.6 | 82.3 ± 5.1 |
39d | 4- OCH3 | 2-F | 25.4 ± 1.7 | 35.8 ± 1.4 | 81.3 ± 2.1 |
39e | 4- OCH3 | 2-Cl | 43.5 ± 2.2 | 46.1 ± 2.6 | 77.7 ± 2.0 |
39f | 4- OCH3 | 2,4-Di-Cl | 43.9 ± 2.4 | 49.6 ± 1.8 | 85.6 ± 1.9 |
39g | 4- OCH3 | H | 37.8 ± 1.6 | 42.5 ± 2.0 | 78.8 ± 2.1 |
39h | 4- OCH3 | 4-CH3 | 26.5 ± 1.2 | 42.1 ± 2.1 | 86.3 ± 5.4 |
39i | 4- OCH3 | 4-OCH3 | 35.1 ± 1.5 | 41.5 ± 1.8 | 81.5 ± 2.6 |
39j | 4- OCH3 | 2-CF3 | 30.5 ± 2.1 | 49.3 ± 2.3 | 77.9 ± 4.5 |
38k | H | 2,4-Di-F | 55.4 ± 2.8 | 71.3 ± 1.9 | 85.2 ± 4.0 |
Ribavirin |  |  | 37.9 ± 1.9 | 51.8 ± 2.3 | 72.9 ± 2.4 |