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Table 1 IC50 inhibition of COX1 and COX2, Selectivity ratio for COX1/COX2, and the CC50 on HeLa cancer cell line of the synthesized compounds

From: Design, synthesis and biological evaluation of novel benzodioxole derivatives as COX inhibitors and cytotoxic agents

The IC50 in µM of COX 1 and COX2 COX1/COX2 Ratio HeLa Cell CC50 in milli-molar
Codes X R1 R2 R3 COX1 COX2 Selectivity CC50
3a O-CH3 H H H 12.320 14.340 0.859 1.49
3b O-CH3 I H H 1.120 1.300 0.862 0.228
3c O-CH3 H I H 27.060 37.450 0.723 1.79
3d O-CH3 Br H H 1.3 1.45 0.897 1.61
3e O-CH3 H Br H 2.360 2.730 0.864 0.219
3f O-CH3 Cl H Cl 5.180 4.100 1.263 0.949
4a OH H H H 1.450 3.340 0.434 1.94
4b OH I H H 7.670 30.700 0.250 0.697
4c OH H I H 33.700 39.140 0.861 1.049
4d OH Br H H 4.250 2.350 1.809 0.547
4e OH H Br H 7.110 49.300 0.144 0.437
4f OH Cl H Cl 0.725 4.290 0.169 1.019
Ketoprofen   0.031 0.158 0.196  
  1. P-values for the experiments p < 0.05
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BMC Chemistry

ISSN: 2661-801X

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