|
The IC50 in µM of COX 1 and COX2
|
COX1/COX2 Ratio
|
HeLa Cell CC50 in milli-molar
|
---|
Codes
|
X
|
R1
|
R2
|
R3
|
COX1
|
COX2
|
Selectivity
|
CC50
|
3a
|
O-CH3
|
H
|
H
|
H
|
12.320
|
14.340
|
0.859
|
1.49
|
3b
|
O-CH3
|
I
|
H
|
H
|
1.120
|
1.300
|
0.862
|
0.228
|
3c
|
O-CH3
|
H
|
I
|
H
|
27.060
|
37.450
|
0.723
|
1.79
|
3d
|
O-CH3
|
Br
|
H
|
H
|
1.3
|
1.45
|
0.897
|
1.61
|
3e
|
O-CH3
|
H
|
Br
|
H
|
2.360
|
2.730
|
0.864
|
0.219
|
3f
|
O-CH3
|
Cl
|
H
|
Cl
|
5.180
|
4.100
|
1.263
|
0.949
|
4a
|
OH
|
H
|
H
|
H
|
1.450
|
3.340
|
0.434
|
1.94
|
4b
|
OH
|
I
|
H
|
H
|
7.670
|
30.700
|
0.250
|
0.697
|
4c
|
OH
|
H
|
I
|
H
|
33.700
|
39.140
|
0.861
|
1.049
|
4d
|
OH
|
Br
|
H
|
H
|
4.250
|
2.350
|
1.809
|
0.547
|
4e
|
OH
|
H
|
Br
|
H
|
7.110
|
49.300
|
0.144
|
0.437
|
4f
|
OH
|
Cl
|
H
|
Cl
|
0.725
|
4.290
|
0.169
|
1.019
|
Ketoprofen
| |
0.031
|
0.158
|
0.196
| |
- P-values for the experiments p < 0.05