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Table 2 In vitro antimicrobial activity of the synthesized compounds

From: Design, synthesis, in silico studies and biological evaluation of 5-((E)-4-((E)-(substituted aryl/alkyl)methyl)benzylidene)thiazolidine-2,4-dione derivatives

Comp.

Antimicrobial screening (MIC = µM)

SA

BS

EC

KP

ST

CA

AN

1

81.1

40.5

81.1

40.5

40.5

40.5

40.5

2

101.2

50.6

50.6

50.6

50.6

50.6

50.6

3

77.3

38.6

77.3

38.6

38.6

38.6

38.6

4

18.2

36.5

73.0

36.5

36.5

36.5

36.5

5

36.5

36.5

73.0

36.5

36.5

36.5

36.5

6

40.0

40.0

80.1

40.0

40.0

40.0

40.0

7

38.8

38.8

77.6

38.8

38.8

38.8

38.8

8

77.6

38.8

77.6

38.8

38.8

38.8

38.8

9

37.2

37.2

74.4

18.6

18.6

37.2

37.2

10

74.4

18.6

74.4

37.2

37.2

37.2

37.2

11

38.3

38.3

19.2

38.3

38.3

38.3

38.3

12

32.2

32.2

64.5

32.2

32.2

16.1

32.2

13

17.9

35.9

70.8

17.9

35.9

17.9

17.9

14

64.6

32.3

64.6

32.3

32.3

32.3

32.3

15

74.0

37.0

74.0

37.0

18.5

18.5

18.5

16

74.0

18.5

37.0

37.0

37.0

37.0

37.0

17

74.0

37.0

74.0

37.0

74.0

37.0

37.0

18

76.6

38.3

38.3

38.3

38.3

38.3

38.3

19

35.9

35.9

35.9

35.9

35.9

35.9

35.9

20

31.3

31.3

62.5

31.3

31.3

31.3

31.3

Cefadroxil

34.4

34.4

17.2

34.4

34.4

Fluconazole

40.8

40.8

  1. Italic signifies best MIC values against selected microbial strains
  2. SA: Staphylococcus aureus, BS: Bacillus subtilis, EC: Escherichia coli, KP: Klebsiella pneumoniae, ST: Salmonella typhi; CA: Candida albicans, AN: Aspergillus niger