Table 1 Cytotoxic activities of tested compounds against liver carcinoma cell line (HEPG2)
From: Facile synthesis and antiproliferative activity of new 3-cyanopyridines
Compd no. | R | R′ | IC50 (μM) |
|---|---|---|---|
Doxorubicin | – | – | 0.72 |
5a | C6H5 |
| 22.3 |
5b | 4-MeC6H4 | 40.9 | |
5c |
| 1.46 | |
5d |
| 7.08 | |
9a | C6H5 |
| 42.8 |
9b | 4-MeC6H4 | 65.3 | |
9c |
| 23.9 | |
9d |
| 66.5 | |
13a | C6H5 | – | 74.3 |
13b | 4-MeC6H4 | 92.5 | |
13c |
| 39.0 | |
13d |
| 72.4 |
