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Table 2 In vitro inhibition activity of compounds A1, A2, A3, A4 and A5 on inflammatory mediators in macrophages

From: gem-Difluorobisarylic derivatives: design, synthesis and anti-inflammatory effect

Compounds IC50 (μM)
IL-6 NO
A1 ND ND
A2 64.5 ± 21.1a 45.2 ± 24.6
A3 60 ± 60.2 ND
A4 51.2 ± 17.4 18.5 ± 2.7
A5 82.6 ± 24.0 40.9 ± 25.4
Fenoprofen 300 ± 100 43.8 ± 39.2
  1. ND not determined
  2. aMean ± SEM