Table 2 In vitro inhibition activity of compounds A1, A2, A3, A4 and A5 on inflammatory mediators in macrophages
From: gem-Difluorobisarylic derivatives: design, synthesis and anti-inflammatory effect
Compounds | IC50 (μM) | |
|---|---|---|
IL-6 | NO | |
A1 | ND | ND |
A2 | 64.5 ± 21.1a | 45.2 ± 24.6 |
A3 | 60 ± 60.2 | ND |
A4 | 51.2 ± 17.4 | 18.5 ± 2.7 |
A5 | 82.6 ± 24.0 | 40.9 ± 25.4 |
Fenoprofen | 300 ± 100 | 43.8 ± 39.2 |