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Table 1 Preparation of five bisarylic compounds
structurea

From: gem-Difluorobisarylic derivatives: design, synthesis and anti-inflammatory effect

Compound X R1 R2
A1 C=O –CO2CH3
A2 CF2 –CO2CH3
A3 CF2 Br –CO2H
A4 CF2 –COCH3 –CO2H
A5 CF2 –CH(CH3)2 –CO2H