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Table 9 Precision data for the determination of SFV by Method 2

From: Two novel UPLC methods utilizing two different analytical columns and different detection approaches for the simultaneous analysis of velpatasvir and sofosbuvir: application to their co-formulated tablet

Parameters

Column (A)

Column (B)

Concentration (ng/mL)

Concentration (ng/mL)

30

70

150

30

70

150

Intraday

 % Found

98.69

99.41

99.82

99.47

99.77

99.93

103.37

101.32

100.28

100.54

99.53

100.10

100.70

99.55

100.05

100.84

99.95

100.08

 (\( \overline{{\text{x}}} \))

100.92

100.09

100.05

100.28

99.75

100.04

 ± SD

2.35

1.07

0.23

0.72

0.21

0.09

 %RSD

2.33

1.06

0.23

0.72

0.21

0.09

 %Error

1.34

0.61

0.13

0.42

0.12

0.05

Inter-day

 % Found

100.34

99.79

99.86

103.21

97.25

100.68

100.35

99.96

100.01

97.48

95.95

99.91

100.38

99.77

99.98

98.07

98.73

99.75

 (\( \overline{{\text{x}}} \))

100.36

99.84

99.95

99.59

97.31

100.11

 ± SD

0.02

0.10

0.08

3.15

1.39

0.50

 %RSD

0.02

0.10

0.08

3.17

1.43

0.50

 %Error

0.01

0.06

0.05

1.83

0.83

0.29

  1. Each result is the average of three separate determinations