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Table 9 Precision data for the determination of SFV by Method 2

From: Two novel UPLC methods utilizing two different analytical columns and different detection approaches for the simultaneous analysis of velpatasvir and sofosbuvir: application to their co-formulated tablet

Parameters Column (A) Column (B)
Concentration (ng/mL) Concentration (ng/mL)
30 70 150 30 70 150
Intraday
 % Found 98.69 99.41 99.82 99.47 99.77 99.93
103.37 101.32 100.28 100.54 99.53 100.10
100.70 99.55 100.05 100.84 99.95 100.08
 (\( \overline{{\text{x}}} \)) 100.92 100.09 100.05 100.28 99.75 100.04
 ± SD 2.35 1.07 0.23 0.72 0.21 0.09
 %RSD 2.33 1.06 0.23 0.72 0.21 0.09
 %Error 1.34 0.61 0.13 0.42 0.12 0.05
Inter-day
 % Found 100.34 99.79 99.86 103.21 97.25 100.68
100.35 99.96 100.01 97.48 95.95 99.91
100.38 99.77 99.98 98.07 98.73 99.75
 (\( \overline{{\text{x}}} \)) 100.36 99.84 99.95 99.59 97.31 100.11
 ± SD 0.02 0.10 0.08 3.15 1.39 0.50
 %RSD 0.02 0.10 0.08 3.17 1.43 0.50
 %Error 0.01 0.06 0.05 1.83 0.83 0.29
  1. Each result is the average of three separate determinations