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Table 1 The microsomal intrinsic clearance of NQC of different species’ liver microsomes calculated based on the available data

From: Construction of a novel quinoxaline as a new class of Nrf2 activator

Species of liver microsome T1/2 (min) mCint (mL/min/g liver) Rate of metabolism (min−1)
Human 63.30 ± 1.73 1.14 ± 0.31 0.011
Rat 52.23 ± 0.81 1.39 ± 0.87 0.013
Mouse 24.55 ± 1.13 2.96 ± 0.34 0.028