Table 1 The microsomal intrinsic clearance of NQC of different species’ liver microsomes calculated based on the available data
From: Construction of a novel quinoxaline as a new class of Nrf2 activator
Species of liver microsome | T1/2 (min) | mCint (mL/min/g liver) | Rate of metabolism (min−1) |
|---|---|---|---|
Human | 63.30 ± 1.73 | 1.14 ± 0.31 | 0.011 |
Rat | 52.23 ± 0.81 | 1.39 ± 0.87 | 0.013 |
Mouse | 24.55 ± 1.13 | 2.96 ± 0.34 | 0.028 |