Table 6 ADME assessment of compounds 2a–2h
ADME properties | 2a | 2b | 2c | 2d | 2e | 2f | 2g | 2h |
|---|---|---|---|---|---|---|---|---|
Absorption | ||||||||
 WS (log mol/L) | − 3.147 | − 3.599 | − 3.644 | − 3.8 | − 3.901 | − 3.538 | − 3.742 | − 4.122 |
 IS (% abs) | 95.067 | 92.136 | 93.112 | 92.486 | 94.048 | 94.329 | 91.609 | 95.929 |
 SP (logKp) | − 2.46 | − 2.865 | − 2.826 | − 2.837 | − 2.943 | − 2.508 | − 2.908 | − 2.61 |
Distribution | ||||||||
 BBBP (logBB) | 0.055 | − 0.545 | − 0.549 | − 0.574 | − 0.726 | 0.389 | − 0.518 | 0.291 |
 CNSP (logPS) | − 2.215 | − 2.407 | − 2.905 | − 2.915 | − 2.973 | − 2.768 | − 2.864 | − 2.772 |
Metabolism | ||||||||
 CYP3A4 inhibitor | Yes | No | No | No | No | No | No | No |
Excretion | ||||||||
 TC (log mL/min/kg) | 0.297 | 0.248 | 0.192 | 0.07 | 0.273 | 0.254 | 0.278 | 0.278 |