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Table 6 ADME assessment of compounds 2a2h

From: Designing, synthesis and characterization of 2-aminothiazole-4-carboxylate Schiff bases; antimicrobial evaluation against multidrug resistant strains and molecular docking

ADME properties 2a 2b 2c 2d 2e 2f 2g 2h
Absorption
 WS (log mol/L) − 3.147 − 3.599 − 3.644 − 3.8 − 3.901 − 3.538 − 3.742 − 4.122
 IS (% abs) 95.067 92.136 93.112 92.486 94.048 94.329 91.609 95.929
 SP (logKp) − 2.46 − 2.865 − 2.826 − 2.837 − 2.943 − 2.508 − 2.908 − 2.61
Distribution
 BBBP (logBB) 0.055 − 0.545 − 0.549 − 0.574 − 0.726 0.389 − 0.518 0.291
 CNSP (logPS) − 2.215 − 2.407 − 2.905 − 2.915 − 2.973 − 2.768 − 2.864 − 2.772
Metabolism
 CYP3A4 inhibitor Yes No No No No No No No
Excretion
 TC (log mL/min/kg) 0.297 0.248 0.192 0.07 0.273 0.254 0.278 0.278
  1. WS water solubility, IS intestinal solubility (% abs absorption), SP skin permeability, BBBP blood brain barrier permeability, CNSP Central Nervous System permeability, TC total clearance