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Table 31 Antimalarial activity of benzimidazole derivatives (30a and 30b)

From: Pharmacological significance of heterocyclic 1H-benzimidazole scaffolds: a review

Comp. IβHS IC50 (µM) IGP % P SD
30a 95.43 ± 0.58 8.43 0 4.02 ± 0.45 17 ± 1.26
30b 75.76 ± 0.99 11.10 14.08 ± 0.88 1.8 ± 0.49 18.8 ± 2.05
Leupeptin 91.62 ± 0.69
Pepstatin 95.45 ± 0.66
Chloroquine 94.19 ± 0.36 24.12 ± 1.16 1.3 ± 0.3 > 30
Saline Solution 21.8 ± 2.31 11.66 ± 1.66