Table 30 Antihistamine, receptor binding and anti-PAF activities
From: Pharmacological significance of heterocyclic 1H-benzimidazole scaffolds: a review
Comp. | Anti H1 activity ileum IC50 (µmol/L) | H1 receptor binding IC50 (µmol/L) | PAF-induced platelet Aggregation IC50 (µmol/L) |
|---|---|---|---|
27a | 0.00794 | 0.000881 | 78 |
Desloratadine | 0.0721 | 0.00588 | 130 |
Astermizole | 0.0453 | 0.004 | ND |