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Table 30 Antihistamine, receptor binding and anti-PAF activities

From: Pharmacological significance of heterocyclic 1H-benzimidazole scaffolds: a review

Comp. Anti H1 activity ileum IC50 (µmol/L) H1 receptor binding IC50 (µmol/L) PAF-induced platelet
Aggregation IC50 (µmol/L)
27a 0.00794 0.000881 78
Desloratadine 0.0721 0.00588 130
Astermizole 0.0453 0.004 ND