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Table 24 Analgesic activities of benzimidazole compounds 21a-c via Tail-flick method

From: Pharmacological significance of heterocyclic 1H-benzimidazole scaffolds: a review

Comp.

(Mean ± SEM) tail withdrawing time in second

0 h

1 h

2 h

3 h

4 h

Control (0.5% CMC)

1.56 ± 0.16

2.16 ± 0.16

2.33 ± 0.21

2.66 ± 0.21

2.82 ± 0.72

Pentazocine

2.16 ± 0.16

8.5 ± 0.34

11.33 ± 0.21

10.16 ± 0.30

10.83 ± 0.30

21a

2.0 ± 0.25

3.0 ± 0.25

4.16 ± 0.33

10.5 ± 0.22

9.83 ± 0.33

21b

2.0 ± 0.25

4.33 ± 0.21

3.73 ± 0.30

8.63 ± 0.21

10.03 ± 0.30

21c

2.0 ± 0.25

6.51 ± 0.21

7.83 ± 0.30

9.73 ± 0.21

9.25 ± 0.30

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BMC Chemistry

ISSN: 2661-801X

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