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Table 24 Analgesic activities of benzimidazole compounds 21a-c via Tail-flick method

From: Pharmacological significance of heterocyclic 1H-benzimidazole scaffolds: a review

Comp. (Mean ± SEM) tail withdrawing time in second
0 h 1 h 2 h 3 h 4 h
Control (0.5% CMC) 1.56 ± 0.16 2.16 ± 0.16 2.33 ± 0.21 2.66 ± 0.21 2.82 ± 0.72
Pentazocine 2.16 ± 0.16 8.5 ± 0.34 11.33 ± 0.21 10.16 ± 0.30 10.83 ± 0.30
21a 2.0 ± 0.25 3.0 ± 0.25 4.16 ± 0.33 10.5 ± 0.22 9.83 ± 0.33
21b 2.0 ± 0.25 4.33 ± 0.21 3.73 ± 0.30 8.63 ± 0.21 10.03 ± 0.30
21c 2.0 ± 0.25 6.51 ± 0.21 7.83 ± 0.30 9.73 ± 0.21 9.25 ± 0.30