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Table 2 Substrate scope of reaction between various aromatic aldehydes and cyclohexanedione

From: Sulfonic acid-functionalized polyallylamine (sevelamer) as an efficient reusable strong solid acid catalyst for the synthesis of xanthenes derivatives

EntryR(Ar)–Time (min)ProductYield (%)amp (°C)
1Ph303a94213–215
24-CH3Ph453b91244–246
34-CH3OPh453c92190–191
44-ClPh303d93289–291
52-ClPh303e91250–252
64-FPh303f93277–278
74-NO2Ph303g90234–236
8Ph504a90202–204
94-CH3Ph504b89215–217
104-ClPh454c91230–232
114-FPh454d90223–225
122,4-diClPh454e88219–221
  1. Reaction conditions: 1 (1.0 mmol), 2 (2.0 mmol), S-SO3H (10 mg), water (1.0 mL), 90 °C
  2. aIsolated yield