BMC Chemistry

Table 2 Substrate scope of reaction between various aromatic aldehydes and cyclohexanedione

From: Sulfonic acid-functionalized polyallylamine (sevelamer) as an efficient reusable strong solid acid catalyst for the synthesis of xanthenes derivatives


Entry	R(Ar)–	Time (min)	Product	Yield (%)^a	mp (°C)
1	Ph	30	3a	94	213–215
2	4-CH₃Ph	45	3b	91	244–246
3	4-CH₃OPh	45	3c	92	190–191
4	4-ClPh	30	3d	93	289–291
5	2-ClPh	30	3e	91	250–252
6	4-FPh	30	3f	93	277–278
7	4-NO₂Ph	30	3g	90	234–236
8	Ph	50	4a	90	202–204
9	4-CH₃Ph	50	4b	89	215–217
10	4-ClPh	45	4c	91	230–232
11	4-FPh	45	4d	90	223–225
12	2,4-diClPh	45	4e	88	219–221

Reaction conditions: 1 (1.0 mmol), 2 (2.0 mmol), S-SO₃H (10 mg), water (1.0 mL), 90 °C
^aIsolated yield

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ISSN: 2661-801X

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