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Table 2 Linear regression parameters between the logarithm of the retention factor (log k) and methanol volume fraction (φ)

From: Assessment of lipophilicity of newly synthesized celecoxib analogues using reversed-phase HPLC

Compound log k = log kw − S\(\varphi\)
Log kw SDa S SDb r R2 Syx F \(\varphi\) 0 Range
11a 2.593 ± 0.331 − 0.040 ± 0.005 0.9804 0.9610 0.074 74.10 64.83 60–80
11b 3.597 ± 0.826 − 0.052 ± 0.012 0.9301 0.8650 0.186 19.25 69.81 60–80
11c 3.151 ± 0.359 − 0.042 ± 0.005 0.9785 0.9570 0.081 67.59 75.14 60–80
11d 4.784 ± 0.887 − 0.061 ± 0.012 0.9627 0.9270 0.136 25.30 77.99 65–80
16a 1.941 ± 0.413 − 0.030 ± 0.006 0.9475 0.8980 0.092 26.34 64.39 60–80
16b 2.715 ± 0.442 − 0.037 ± 0.006 0.9602 0.9220 0.099 35.47 72.57 60–80
17a 4.590 ± 1.091 − 0.059 ± 0.015 0.9098 0.8280 0.245 14.41 77.97 60–80
17b 5.182 ± 1.017 − 0.069 ± 0.014 0.9409 0.8850 0.229 23.14 74.52 60–80
Celecoxib 4.180 ± 0.445 − 0.048 ± 0.006 0.9847 0.9696 0.068 63.81 85.51 65–80
  1. SDa, standard deviation of intercept; SDb, standard deviation of slope, r, correlation coefficient, R2, determination coefficient, Syx, standard error of estimate (SEE); F, value of test F Snedecora at P value < 0.05; \(\varphi\)0, the hydrophobicity index