Skip to main content

Table 5 Pharmacokinetic parameters for metformin and canagliflozin following oral administration of one Vokanamet® nominally containing 850 mg of metformin and 50 mg of canagliflozin

From: Novel LC–MS/MS method for analysis of metformin and canagliflozin in human plasma: application to a pharmacokinetic study

PK parameter

Metformin

Canagliflozin

tmax (h)

3.5 ± 0.71

4 ± 0.0

Cmax (ng/mL)

1197.50 ± 470.23

383.13 ± 62.41

AUC0−t (ng h/mL)

11849.18 ± 5871.57

3409.06 ± 208.50

AUC0−∞ (ng h/mL)

12575.62 ± 6220.67

3962.65 ± 223.77

t1/2 (h)

6.03 ± 0.62

8.19 ± 0.06

Kel (h−1)

0.12 ± 0.01

0.08 ± 0.01

Back to article page

BMC Chemistry

ISSN: 2661-801X

Contact us