Table 7 The interaction of highly active compounds with binding pocket of bacterial dihydrofolate reductase (PDB ID 3SRW)

C-6

Ala8, Val7, Leu6, Phe93, Phe99, Ile15, Asn19, Gln20, Leu21, Trp23

C-8

Lys33, Val32, Lys30, Leu29, Asp28, Phe93, Leu6, Val7, Ala8, Ile15, Trp23, Leu21

C-24

Val32, Phe93, Leu29, Asp28, Trp23, Leu21, Gln20, Asn19,Ile15, Thr47,Ser50, Ile51

C-25

Leu6, Val7, Ala8, Phe99, Gln96, Phe93, Thr122, Ile15,Asn19, Gln20, Leu21, Trp23

C-27

Leu55, Asp28, Leu29, Val32, Leu6, Val7, Ala8, Phe99, Thr122, Gln96, Phe99, Ile15, Asn19, Gln20, Leu21, Trp23

Trimethoprim

Asp28, Leu29, Val32, Ala8, Val7, Phe93, Leu6, Phe99, Ile15, Asn19, Gln20, Leu21