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Table 4 IC50 (µg ml−1) of synthesized diazenyl chalcones against A549 and HEK cell line

From: Antimicrobial, antioxidant and cytotoxic evaluation of diazenyl chalcones along with insights to mechanism of interaction by molecular docking studies

Compound

A549

IC50 (µg ml−1)

HEK

IC50 (µg ml−1)

Ratio (HEK/A549)

IC50 (µg ml−1)

C-19

140.17 ± 1.11

221.06 ± 3.23

1.58

C-22

156.45 ± 1.23

296.45 ± 2.32

1.90

C-23

171.31 ± 2.46

190.11 ± 1.56

1.11

C-24

108.89 ± 3.21

280.45 ± 1.21

2.59

C-25

18.01 ± 1.34

270.23 ± 2.82

15.00

C-27

123.52 ± 2.56

330.56 ± 2.90

2.67

Std

8.7

9.0 [28]

1.03

  1. Std camptothecin, A549 human lung cancer cell line, HEK human embryonic kidney cells
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BMC Chemistry

ISSN: 2661-801X

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