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Table 6 Assay results for the determination of the FF and GLY in their synthetic mixture by the proposed IPC and reference methods

From: Multiple analytical methods for determination of formoterol and glycopyrronium simultaneously in their novel combined metered dose inhaler

  Proposed IPC method (synthetic mixture) Reference method [39]
Conc. taken (μg/mL) % Founda Conc. taken (μg/mL) % Founda
FF GLY FF GLY FF GLY FF GLY
Data 3.6 6.75 99.42 100.12 9.6 13.5 99.38 99.58
3.0 5.625 99.34 100.82 7.2 11.25 98.34 98.32
2.4 4.5 100.35 100.4 4.8 9.0 99.25 99.25
1.8 3.375 100.97 100.35 3.6 6.75 100.38 99.87
1.2 2.25 99.57 99.49 2.4 4.5 99.07 100.77
0.6 1.125 99.34 99.18 1.2 2.25 98.34 100.82
\({\bar{\text{X}}}\)   99.83 100.06   99.13 99.77
± SD 0.68 0.61 0.76 0.95
t-value 1.7 (10.0) 0.63 (10.0)  
F-value 1.27 (5.5) 2.41 (5.5)
  1. Nominal content for GLY in Bevespi® aerosphere by the proposed method = 9.0 μg/buff
  2. Each result is the average of three separate determinations
  3. aNominal content for FF in Bevespi® aerosphere by the proposed method = 4.8 μg/buff
  Proposed IPC method (MDI) Reference method [39]
Conc. taken (μg/mL) % Founda Conc. taken (μg/mL) % Founda
FF GLY FF GLY FF GLY FF GLY
Data 3.6 6.75 99.87 100.52 9.6 13.5 99.94 100.85
2.7 5.625 99.68 100.33 7.2 11.25 99.88 100.35
1.8 4.5 99.35 100.08 4.8 9.0 100.94 100.39
0.9 3.375 100.87 99.52 3.6 6.75 99.72 98.33
0.45 2.25 100.24 99.68 2.4 4.5 99.40 99.58
0.36 1.125 99.34 100.48 1.2 2.25 99.24 99.07
\({\bar{\text{X}}}\)   99.89 100.1   99.85 99.76
± SD 0.59 0.42 0.60 0.95
t-value 0.11 (10.0) 0.8 [10]  
F-value 1.04 (5.5) 5.06 (5.5)
  1. Nominal content for GLY in Bevespi® aerosphere by the proposed method = 9.0 μg/buff
  2. Each result is the average of three separate determinations
  3. aNominal content for FF in Bevespi® aerosphere by the proposed method = 4.8 μg/buff