Skip to main content

Advertisement

Table 3 IC50 values (in µg/ml) of indole diazenyl derivatives against various cell lines

From: Indole hybridized diazenyl derivatives: synthesis, antimicrobial activity, cytotoxicity evaluation and docking studies

Compound HCT 116a MDA MB 231b K562c HEK-293d
IC50 (µg/ml)
 DS-2 116.57 ± 4.28 57.63 ± 3.68 140.05 ± 4.40 280.24. ± 1.74
 DS-3 110.03 ± 2.55 45.96 ± 1.83 146.08 ± 2.11 311.17 ± 1.76
 DS-6 139.19 ± 4.29 118.73 ± 1.92 187.76 ± 1.94 257.84 ± 0.57
 DS-10 204.93 ± 1.62 129.66 ± 3.51 198.55 ± 3.13 274.12 ± 4.58
 DS-14 54.03 ± 1.96 19.10 ± 1.43 112.26 ± 3.64 244.15 ± 3.78
 DS-20 66.66 ± 1.56 20.95 ± 1.93 135.80 ± 4.74 232.69 ± 4.68
 DS-21 124.80 ± 1.33 49.30 ± 4.15 157.95 ± 3.73 141.92 ± 3.25
 DOX 3.37 ± 0.37 3.08 ± 0.95 2.62 ± 0.65 NT
  1. IC50 = 50% Inhibitory concentration after 48 h of drug treatment
  2. DOX doxorubicin, NT not tested
  3. aColon cancer
  4. bBreast cancer
  5. cLeukemia
  6. dNormal cells