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Table 3 IC50 values (in µg/ml) of indole diazenyl derivatives against various cell lines

From: Indole hybridized diazenyl derivatives: synthesis, antimicrobial activity, cytotoxicity evaluation and docking studies

Compound

HCT 116a

MDA MB 231b

K562c

HEK-293d

IC50 (µg/ml)

 DS-2

116.57 ± 4.28

57.63 ± 3.68

140.05 ± 4.40

280.24. ± 1.74

 DS-3

110.03 ± 2.55

45.96 ± 1.83

146.08 ± 2.11

311.17 ± 1.76

 DS-6

139.19 ± 4.29

118.73 ± 1.92

187.76 ± 1.94

257.84 ± 0.57

 DS-10

204.93 ± 1.62

129.66 ± 3.51

198.55 ± 3.13

274.12 ± 4.58

 DS-14

54.03 ± 1.96

19.10 ± 1.43

112.26 ± 3.64

244.15 ± 3.78

 DS-20

66.66 ± 1.56

20.95 ± 1.93

135.80 ± 4.74

232.69 ± 4.68

 DS-21

124.80 ± 1.33

49.30 ± 4.15

157.95 ± 3.73

141.92 ± 3.25

 DOX

3.37 ± 0.37

3.08 ± 0.95

2.62 ± 0.65

NT

  1. IC50 = 50% Inhibitory concentration after 48 h of drug treatment
  2. DOX doxorubicin, NT not tested
  3. aColon cancer
  4. bBreast cancer
  5. cLeukemia
  6. dNormal cells
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BMC Chemistry

ISSN: 2661-801X

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