4-(4-Bromophenyl)-thiazol-2-amine derivatives: synthesis, biological activity and molecular docking study with ADME profile

Table 1 Physicochemical properties of the synthesized compounds (p1–p10)

S. no	Compound		Molecular formula	Color	m.pt. °C	R_f value	% Yield
1	(p1)	4-(4-Bromophenyl)-N-(3,4-dimethoxybenzylidene)thiazol-2-amine	C₁₈H₁₅N₂SBrO₂	Light yellow	134–136	0.45	85
2	(p2)	4-((4-(4-Bromophenyl)thiazol-2-ylimino)methyl)-2-methoxyphenol	C₁₇H₁₃N₂SBrO₂	Creamy yellow	122–125	0.38	70
3	(p3)	4-(4-Bromophenyl)-N-(4-(dimethylamino)benzylidene)thiazol-2-amine	C₁₈H₁₆N₃SBr	Yellowish white	117–120	0.25	65
4	(p4)	N-(3,4,5-Trimethoxybenzylidene)-4-(4-bromophenyl)thiazol-2-amine	C₁₉H₁₇N₂SBrO₃	Greenish yellow	105–107	0.30	75
5	(p5)	N-(4-Bromobenzylidene)-4-(4-bromophenyl)thiazol-2-amine	C₁₆H₁₀N₂SBr₂	Dark yellow	62–64	0.38	69
6	(p6)	1-((4-(4-Bromophenyl)thiazol-2-ylimino)methyl)naphthalen-2-ol	C₂₀H₁₃BrN₂OS	Light yellow	105–107	0.30	72
7	(p7)	N-(4-Chlorobenzylidene)-4-(4-bromophenyl)thiazol-2-amine	C₁₆H₁₀BrClN₂S	Light yellow	65–70	0.23	83
8	(p8)	N-(2,4-Dimethoxybenzylidene)-4-(4-bromophenyl)thiazol-2-amine	C₁₈H₁₅BrN₂O₂S	Lemon yellow	71–73	0.52	72
9	(p9)	N-(3-Methoxybenzylidene)-4-(4-bromophenyl)thiazol-2-amine	C₁₇H₁₃BrN₂OS	Yellowish white	188–190	0.79	65
10	(p10)	3-(((4-(4-Bromophenyl)thiazol-2-yl)imino)methyl)phenol	C₁₆H₁₁BrN₂OS	Dark yellow	106–108	0.21	71

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