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Table 2 Curative effects of compounds 8c, 8j and 8k against TMV

From: Design, synthesis, antiviral bioactivities and interaction mechanisms of penta-1,4-diene-3-one oxime ether derivatives containing a quinazolin-4(3H)-one scaffold

Compound

Concentration (μg/mL)a

Curative activity (%)a

Toxic regression equation

r

EC50 (μg/mL)

8c

500

55.9 ± 2.9

y = 0.3444x + 4.2222

0.9860

138.5

250

51.2 ± 5.5

125

48.8 ± 4.9

62.5

44.2 ± 5.6

31.25

38.9 ± 5.0

8j

500

55.4 ± 4.3

y = 0.3111x + 4.3085

0.9746

132.9

250

52.2 ± 5.1

125

48.7 ± 5.3

62.5

46.1 ± 5.6

31.25

39.9 ± 4.8

8k

500

59.1 ± 4.2

y = 0.4154x + 4.1258

0.9836

125.6

250

56.1 ± 5.6

125

50.0 ± 3.8

62.5

43.6 ± 3.5

31.25

40.6 ± 5.1

Ningnamycinb

500

51.6 ± 4.3

y = 0.5475x + 3.4987

0.9761

207.3

250

41.2 ± 3.8

125

33.3 ± 2.6

62.5

30.3 ± 4.6

31.25

26.2 ± 3.4

  1. aAverage of three replicates
  2. bNingnanmycin was used as a comparision
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BMC Chemistry

ISSN: 2661-801X

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