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Table 2 Curative effects of compounds 8c, 8j and 8k against TMV

From: Design, synthesis, antiviral bioactivities and interaction mechanisms of penta-1,4-diene-3-one oxime ether derivatives containing a quinazolin-4(3H)-one scaffold

Compound Concentration (μg/mL)a Curative activity (%)a Toxic regression equation r EC50 (μg/mL)
8c 500 55.9 ± 2.9 y = 0.3444x + 4.2222 0.9860 138.5
250 51.2 ± 5.5
125 48.8 ± 4.9
62.5 44.2 ± 5.6
31.25 38.9 ± 5.0
8j 500 55.4 ± 4.3 y = 0.3111x + 4.3085 0.9746 132.9
250 52.2 ± 5.1
125 48.7 ± 5.3
62.5 46.1 ± 5.6
31.25 39.9 ± 4.8
8k 500 59.1 ± 4.2 y = 0.4154x + 4.1258 0.9836 125.6
250 56.1 ± 5.6
125 50.0 ± 3.8
62.5 43.6 ± 3.5
31.25 40.6 ± 5.1
Ningnamycinb 500 51.6 ± 4.3 y = 0.5475x + 3.4987 0.9761 207.3
250 41.2 ± 3.8
125 33.3 ± 2.6
62.5 30.3 ± 4.6
31.25 26.2 ± 3.4
  1. aAverage of three replicates
  2. bNingnanmycin was used as a comparision