BMC Chemistry

Table 2 Optimization of reaction conditions using various solvents

From: Design and preparation of Fe₃O₄@PVA polymeric magnetic nanocomposite film and surface coating by sulfonic acid via in situ methods and evaluation of its catalytic performance in the synthesis of dihydropyrimidines

Entry	Solvent	Catalyst	Time (min)	Conditions	Yield^a (%)
1	EtOH	–	–	Reflux	Trace
2	EtOH	Fe₃O₄@PVA	50	Reflux	Trace
3	EtOH	Fe₃O₄@PVA-SO₃H	10	Reflux	99
4	EtOH	Fe₃O₄@PVA-SO₃H	20	r.t.	70
5	MeOH	Fe₃O₄@PVA-SO₃H	10	Reflux	90
6	H₂O	Fe₃O₄@PVA-SO₃H	20	Reflux	65
7	CH₃CN	Fe₃O₄@PVA-SO₃H	10	Reflux	85
8	PEG-400	Fe₃O₄@PVA-SO₃H	20	Reflux	95
9	CH₂Cl₂	Fe₃O₄@PVA-SO₃H	20	Reflux	68

^a Isolated yield

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ISSN: 2661-801X

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