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Table 2 Optimization of reaction conditions using various solvents

From: Design and preparation of Fe3O4@PVA polymeric magnetic nanocomposite film and surface coating by sulfonic acid via in situ methods and evaluation of its catalytic performance in the synthesis of dihydropyrimidines

Entry Solvent Catalyst Time (min) Conditions Yielda (%)
1 EtOH Reflux Trace
2 EtOH Fe3O4@PVA 50 Reflux Trace
3 EtOH Fe3O4@PVA-SO3H 10 Reflux 99
4 EtOH Fe3O4@PVA-SO3H 20 r.t. 70
5 MeOH Fe3O4@PVA-SO3H 10 Reflux 90
6 H2O Fe3O4@PVA-SO3H 20 Reflux 65
7 CH3CN Fe3O4@PVA-SO3H 10 Reflux 85
8 PEG-400 Fe3O4@PVA-SO3H 20 Reflux 95
9 CH2Cl2 Fe3O4@PVA-SO3H 20 Reflux 68
  1. a Isolated yield