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Table 1 The effect of reaction condition on the synthesis of 2,3-diphenyl-2,3-dihydroquinazolin-4(1H)-one under various conditions
figureb

From: Co-aminobenzamid@Al-SBA-15: a favorable catalyst in synthesis of 2,3-dihydroquinazolin-4(1H)-ones

Entry Solvent (condition) Catalyst Time (min) Yielda (%)
1 Solvent-free Co-aminobenzamid@Al-SBA-15 (0.03 g) 80 40
2 Water (reflux) Co-aminobenzamid@Al-SBA-15 (0.03 g) 80 55
3 DCM (reflux) Co-aminobenzamid@Al-SBA-15 (0.03 g) 60 Trace
4 Acetone (reflux) Co-aminobenzamid@Al-SBA-15 (0.03 g) 60 25
5 Acetonitrile (reflux) Co-aminobenzamid@Al-SBA-15 (0.03 g) 90 30
6 Methanol (reflux) Co-aminobenzamid@Al-SBA-15 (0.03 g) 50 70
7 Ethanol (reflux) Co-aminobenzamid@Al-SBA-15 (0.02 g) 25 85
8 Ethanol (reflux) Co-aminobenzamid@Al-SBA-15 (0.03 g) 25 94
9 Ethanol (reflux) Co-aminobenzamid@Al-SBA-15 (0.05 g) 25 93
  1. a Isolated yields