From: Development of a practical synthesis of etravirine via a microwave-promoted amination
Yield/% | ||||||
---|---|---|---|---|---|---|
Tem./°C: | 110 | 120 | 125 | 130 | 135 | 140 |
Time/min | ||||||
5 | 32.4 | 42.1 | 45.3 | 43.2 | 45.2 | 47.6 |
10 | 46.7 | 64.5 | 74.2 | 71.2 | 76.3 | 73.6 |
15 | 64.4 | 78.3 | 82.4 | 85.6 | 85.3 | 85.5 |
20 | 74.3 | 80.8 | 82.6 | 85.3 | 85.6 | 85.1 |
25 | 80.4 | 81.2 | 83.1 | 85.7 | 83.1 | 84.3 |
30 | 82.5 | 81.4 | 82.1 | 84.2 | 84.2 | 84.1 |