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Table 2 Optimization of amination reaction conditions

From: Development of a practical synthesis of etravirine via a microwave-promoted amination

  Yield/%
Tem./°C: 110 120 125 130 135 140
Time/min
5 32.4 42.1 45.3 43.2 45.2 47.6
10 46.7 64.5 74.2 71.2 76.3 73.6
15 64.4 78.3 82.4 85.6 85.3 85.5
20 74.3 80.8 82.6 85.3 85.6 85.1
25 80.4 81.2 83.1 85.7 83.1 84.3
30 82.5 81.4 82.1 84.2 84.2 84.1