Table 3 In vitro anticancer screening of the synthesized compounds
From: Design, synthesis and biological evaluation of 3-(2-aminooxazol-5-yl)-2H-chromen-2-one derivatives
Comp. | Anticancer screening (IC50 = µM) | |
|---|---|---|
Cancer cell lines | ||
HCT116 | MCF7 | |
1 | 221.5 | > 246.1 |
2 | 288.7 | > 288.7 |
3 | > 236.7 | > 236.7 |
4 | > 253.8 | > 253.8 |
5 | > 236.9 | > 236.9 |
6 | > 285.1 | 74.1 |
7 | > 277.0 | 207.7 |
8 | 203.8 | > 279.2 |
9 | > 310.2 | 263.7 |
10 | 192.8 | 262.9 |
11 | > 276.8 | > 276.8 |
12 | 221.4 | 83.0 |
13 | > 253.8 | > 253.8 |
14 | 71.8 | 193.4 |
15 | > 260.4 | > 260.4 |
5-Fluorouracil | 12.7 | – |
Tamoxifen | – | 4.3 |