Table 1 Antibacterial effects of isoxazoles 4a–i
Bacterial species | Products | Antibiotic | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
4a | 4b | 4c | 4d | 4e | 4f | 4g | 4h | 4i | Gentamicin | ||
1310 | MIC | 256 | 128 | – | – | 256 | – | – | – | – | 0.063 |
MBC | 512 | 256 | – | – | 512 | – | – | – | – | 0.063 | |
1290 | MIC | 64 | 256 | – | – | 256 | – | – | – | – | 4 |
MBC | 128 | 512 | – | – | 512 | – | – | – | – | 4 | |
1234 | MIC | – | 32 | – | – | – | – | – | – | – | 2 |
MBC | – | 64 | – | – | – | – | – | – | – | 8 | |
1188 | MIC | – | – | – | 128 | – | – | – | – | – | 0.031 |
MBC | – | – | – | 512 | – | – | – | – | – | 0.063 | |
1855 | MIC | – | 512 | – | 128 | – | – | – | – | – | 16 |
MBC | – | 2048 | – | 256 | – | – | – | – | – | 32 | |
1399 | MIC | – | – | – | 32 | – | – | – | – | – | 8 |
MBC | – | – | – | 128 | – | – | – | – | – | 8 | |
1768 | MIC | 512 | 128 | 256 | 256 | – | 64 | – | – | 128 | 0.5 |
MBC | 1024 | 256 | 1024 | 512 | – | 128 | – | – | 256 | 1 | |
1297 | MIC | 32 | 64 | 32 | 64 | 32 | 32 | 256 | 32 | 64 | 2 |
MBC | 128 | 128 | 64 | 128 | 128 | 64 | 512 | 64 | 128 | 2 | |
1445 | MIC | – | 256 | – | 64 | – | – | – | – | 256 | 2 |
MBC | – | 512 | – | 128 | – | – | – | – | 512 | 2 | |
1240 | MIC | 256 | 512 | – | – | – | – | – | – | – | 1 |
MBC | 512 | 1024 | – | – | – | – | – | – | – | 1 | |
1633 | MIC | – | 64 | – | 256 | 256 | – | – | – | – | 2 |
MBC | – | 128 | – | 512 | 512 | – | – | – | – | 2 | |
1023 | MIC | 128 | – | – | – | 256 | – | – | – | – | 0.063 |
MBC | 512 | – | – | – | 512 | – | – | – | – | 0.063 | |
1435 | MIC | – | – | – | – | 64 | – | – | – | 128 | 1 |
MBC | – | – | – | – | 128 | – | – | – | 512 | 2 | |
1494 | MIC | 32 | – | – | 128 | – | 64 | – | – | – | 1 |
MBC | 64 | – | – | 512 | – | 128 | – | – | – | 1 | |
1189 | MIC | 128 | 256 | – | – | 256 | – | 512 | – | – | 1 |
MBC | 512 | 1024 | – | – | 512 | – | 1024 | – | – | 1 | |
1665 | MIC | 256 | 64 | – | 64 | 128 | – | 128 | – | – | 0.25 |
MBC | 512 | 64 | – | 128 | 512 | – | 256 | – | – | 4 | |
1447 | MIC | 64 | 32 | – | 256 | 128 | 512 | – | – | – | 0.063 |
MBC | 128 | 32 | – | 512 | 512 | 512 | – | – | – | 0.125 | |