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Table 1 Antibacterial effects of isoxazoles 4ai

From: Green multicomponent synthesis, antimicrobial and antioxidant evaluation of novel 5-amino-isoxazole-4-carbonitriles

Bacterial species Products Antibiotic
4a 4b 4c 4d 4e 4f 4g 4h 4i Gentamicin
1310 MIC 256 128 256 0.063
MBC 512 256 512 0.063
1290 MIC 64 256 256 4
MBC 128 512 512 4
1234 MIC 32 2
MBC 64 8
1188 MIC 128 0.031
MBC 512 0.063
1855 MIC 512 128 16
MBC 2048 256 32
1399 MIC 32 8
MBC 128 8
1768 MIC 512 128 256 256 64 128 0.5
MBC 1024 256 1024 512 128 256 1
1297 MIC 32 64 32 64 32 32 256 32 64 2
MBC 128 128 64 128 128 64 512 64 128 2
1445 MIC 256 64 256 2
MBC 512 128 512 2
1240 MIC 256 512 1
MBC 512 1024 1
1633 MIC 64 256 256 2
MBC 128 512 512 2
1023 MIC 128 256 0.063
MBC 512 512 0.063
1435 MIC 64 128 1
MBC 128 512 2
1494 MIC 32 128 64 1
MBC 64 512 128 1
1189 MIC 128 256 256 512 1
MBC 512 1024 512 1024 1
1665 MIC 256 64 64 128 128 0.25
MBC 512 64 128 512 256 4
1447 MIC 64 32 256 128 512 0.063
MBC 128 32 512 512 512 0.125
  1. –: No noticeable antibacterial effect at concentration of 10,240 μg ml−1, MIC (μg ml−1), MBC (μg ml−1)