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Table 1 The antitumor activities of the compounds IaIIg

From: Synthesis and antitumor activities of 3-substituted-analine derivatives: structure modifications of Tuv part of tubulysins

Compd. IC50 (μm) Compd. IC50 (μm)
MDA-MB-231 MCF7 MDA-MB-231 MCF7
Ia > 20 > 20 IIa 17.1 > 20
Ib > 20 > 20 IIb 7.6 11.8
Ic > 20 > 20 IIc 16.3 > 20
Id > 20 > 20 IId > 20 15.5
Ie > 20 > 20 IIe 16.3 > 20
Taxol < 0.01 0.006 IIf > 20 > 20
    IIg > 20 > 20