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Table 1 The antitumor activities of the compounds IaIIg

From: Synthesis and antitumor activities of 3-substituted-analine derivatives: structure modifications of Tuv part of tubulysins

Compd.

IC50 (μm)

Compd.

IC50 (μm)

MDA-MB-231

MCF7

MDA-MB-231

MCF7

Ia

> 20

> 20

IIa

17.1

> 20

Ib

> 20

> 20

IIb

7.6

11.8

Ic

> 20

> 20

IIc

16.3

> 20

Id

> 20

> 20

IId

> 20

15.5

Ie

> 20

> 20

IIe

16.3

> 20

Taxol

< 0.01

0.006

IIf

> 20

> 20

   

IIg

> 20

> 20