From: Synthesis and antitumor activities of 3-substituted-analine derivatives: structure modifications of Tuv part of tubulysins
Compd.
IC50 (μm)
MDA-MB-231
MCF7
Ia
> 20
IIa
17.1
Ib
IIb
7.6
11.8
Ic
IIc
16.3
Id
IId
15.5
Ie
IIe
Taxol
< 0.01
0.006
IIf
IIg