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Table 13 Anticancer results (IC50 = µM) of the synthesized derivatives 38–39

From: Estrogen alpha receptor antagonists for the treatment of breast cancer: a review

Compound No. Cancer cell line
T47D
38 15.48 ± 0.10
39 4.99 ± 0.60
Amino acid residues
Met343, Thr 347, Glu 385, Leu 354, Met 357 Trp 383, Glu 353, Leu 384, Leu 387, Met 388, Leu 391, Arg 394, Leu 402,, Met 421, Leu 349, Ile 424, Phe 425, Met 522, Leu 428, Gly 521, His 524, Phe404, Met 517, Leu 525, Met 528, Ser 518, Lys 531Val 534, Pro535, Ser 536, Leu 539, Cys 530, Leu 540 and Ala 350