Table 13 Anticancer results (IC₅₀ = µM) of the synthesized derivatives 38–39

38

15.48 ± 0.10

39

4.99 ± 0.60

Amino acid residues

Met343, Thr 347, Glu 385, Leu 354, Met 357 Trp 383, Glu 353, Leu 384, Leu 387, Met 388, Leu 391, Arg 394, Leu 402,, Met 421, Leu 349, Ile 424, Phe 425, Met 522, Leu 428, Gly 521, His 524, Phe404, Met 517, Leu 525, Met 528, Ser 518, Lys 531Val 534, Pro535, Ser 536, Leu 539, Cys 530, Leu 540 and Ala 350