Identification and characterization of in vivo, in vitro and reactive metabolites of vandetanib using LC–ESI–MS/MS

Table 1 List of chemicals and materials

Name^a	Source
Dacomitinib	LC Laboratories (MA, USA)
Acetonitrile (ACN, HPLC-grade), ammonium formate (NH₄COOH), poly ethylene glycol 300 (PEG 300), dimethyl sulfoxide (DMSO), potassium cyanide (KCN) and formic acid (HCOOH)	Sigma-Aldrich (USA)
Tween 80	Eurostar Scientific Ltd. (Liverpool, UK)
Water (HPLC grade)	Milli-Q plus purification instrument (USA)
Sprague–Dawley rats^b	The experimental animal care center at King Saud University (KSA)

^a All reference powders are of analytical grade and solvent are of HPLC grade
^b The University’s Ethics Review Committee approved the animal experimental design

ISSN: 2661-801X