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Table 4 Fractional inhibitory concentrations (FIC) calculated for the combination of reference antibiotics and compounds 1, 3 and 4 as a function of microorganisms

From: Antimicrobial activities of saponins from Melanthera elliptica and their synergistic effects with antibiotics against pathogenic phenotypes

Microorganisms Compound 1 + ATBa Compound 3 + ATBa Compound 4 + ATBa
∑ FIC Interpretation ∑ FIC Interpretation ∑ FIC Interpretation
E. coli 0.2812 Synergy 0.132 Synergy 0.0664 Synergy
S. flexneri 0.515 Additive 0.257 Synergy 0.0331 Synergy
S. aureus 0.25 Synergy 0.531 Additive 0.0468 Synergy
C. parapsilosis 0.625 Additive 0.156 Synergy 0.187 Synergy
C. albicans 0.187 Synergy 0.0937 Synergy 0.125 Synergy
C. neoformans 0.187 Synergy 0.0937 Synergy 0.0781 Synergy
  1. Σ FIC sum of fractional inhibitory concentrations, ATB antibiotics
  2. aFluconazole for yeasts and tetracycline for bacteria