Antimicrobial activities of saponins from Melanthera elliptica and their synergistic effects with antibiotics against pathogenic phenotypes

Table 3 Antimicrobial activities of the reference antibiotics in the presence of compounds 1, 3 and 4 at 1/4 of MIC as a function of microorganisms

Microorganisms	ATB^a alone	ATB^a with compound 1 at 1/4 of MIC		ATB^a with compound 3 at 1/4 of MIC		ATB^a with compound 4 at 1/4 of MIC
Microorganisms	MIC	MIC	FIC	MIC	FIC	MIC	FIC
E. coli S2 (1)	32	1	0.0312	0.25	0.00781	0.125	0.00390
S. flexneri	16	0.25	0.0156	0.125	0.00781	0.0312	0.00195
S. aureus	2	0.125	0.0625	0.0625	0.0312	0.0312	0.0156
C. parapsilosis	0.5	0.25	0.50	0.0625	0.125	0.0312	0.0625
C. albicans	1	0.125	0.125	0.0625	0.0625	0.0625	0.0625
C. neoformans	2	0.125	0.0625	0.0625	0.0312	0.0312	0.0156

MIC minimal inhibitory concentration, FIC fractional inhibitory concentration, ATB antibiotics
^aFluconazole for yeasts and tetracycline for bacteria; compounds 1, 3 and 4 were tested at the concentration of MIC/4 on the corresponding microorganism

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