Antimicrobial activities of saponins from Melanthera elliptica and their synergistic effects with antibiotics against pathogenic phenotypes

Table 2 Antimicrobial activities of the isolated compounds in the presence of reference antibiotics^a at 1/4 of MIC as a function of microorganisms

Microorganisms	Compound 1 alone	Compound 1 with ATB^a at 1/4 of MIC		Compound 3 alone	Compound 3 with ATB^a at 1/4 of MIC		Compound 4 alone	Compound 4 with ATB^a at 1/4 of MIC
Microorganisms	MIC	MIC	FIC	MIC	MIC	FIC	MIC	MIC	FIC
E. coli	32	8	0.25	128	16	0.125	256	16	0.0625
S. flexneri	16	8	0.5	64	16	0.25	128	4	0.0312
S. aureus	8	1	0.125	32	16	0.50	64	2	0.0312
C. parapsilosis	32	4	0.125	128	4	0.0312	16	2	0.125
C. albicans	64	4	0.0625	128	4	0.0312	16	1	0.0625
C. neoformans	16	2	0.125	32	2	0.0625	8	0.5	0.0625

MIC minimal inhibitory concentration, FIC fractional inhibitory concentration, ATB antibiotics
^aFluconazole for yeasts and tetracycline for bacteria were tested at the concentration of MIC/4 on the corresponding microorganism

ISSN: 2661-801X