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Table 1 Optimization of solvent for synthesis of spiroheterocyclic hybrids 5a

From: Regio and stereoselective synthesis of anticancer spirooxindolopyrrolidine embedded piperidone heterocyclic hybrids derived from one-pot cascade protocol

Entry Solvents Time (h) Yield (%)
1 Methanol 2 90
2 Dioxane 2 62
3 Acetonitrile 2 65
4 Dioxane: methanol 2 75
5 Toluene 2 55
6 [bmim]Br 1 95