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Table 1 Optimization of solvent for synthesis of spiroheterocyclic hybrids 5a

From: Regio and stereoselective synthesis of anticancer spirooxindolopyrrolidine embedded piperidone heterocyclic hybrids derived from one-pot cascade protocol

Entry

Solvents

Time (h)

Yield (%)

1

Methanol

2

90

2

Dioxane

2

62

3

Acetonitrile

2

65

4

Dioxane: methanol

2

75

5

Toluene

2

55

6

[bmim]Br

1

95

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BMC Chemistry

ISSN: 2661-801X

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