Analysis of paracetamol, pseudoephedrine and cetirizine in Allercet Cold® capsules using spectrophotometric techniques

Table 4 Statistical comparison of the results obtained by the proposed spectrophotometric methods and reference method for the determination of PAR, PSE and CET

Parameter	PAR					PSE					CET
Parameter	RSDM	SDR	DRZC	PCCA	Reference method	RSDM	SDR	DRZC	PCCA	Reference method	RSDM	SDR	DRZC	PCCA	Reference method
Mean	99.72	100.1	99.80	100.7	99.40	100.3	100.2	99.39	99.92	100.1	100.1	99.82	99.97	100.1	100.0
SD	0.5870	0.6200	0.9230	1.384	0.7780	0.8050	0.7310	1.130	1.110	0.4270	0.5720	0.5290	0.4290	0.5390	0.2340
N	6	6	6	6	4	6	6	7	6	4	6	6	6	6	4
Variance	0.3450	0.3840	0.8520	1.915	0.6050	0.6480	0.5340	1.277	1.232	0.1820	0.3270	0.2800	0.1840	0.2910	0.05500
Student’s t	0.7570 (2.310)	1.540 (2.310)	0.7130 (2.310)	1.660 (2.310)		0.3310 (2.310)	0.9290 (2.310)	1.200 (2.260)	2.070 (2.310)		0.2380 (2.310)	0.6830 (2.310)	0.2100 (2.310)	0.1290 (2.310)
F	1.760 (5.410)	1.580 (5.410)	1.410 (9.010)	3.170 (9.010)		3.560 (9.010)	2.930 (9.010)	7.020 (8.940)	6.770 (9.010)		5.950 (9.010)	5.090 (9.010)	3.350 (9.010)	5.280 (9.010)

Figures between parentheses represent the corresponding tabulated values of t and F at P = 0.05
The reported method is an HPLC method using C18 column, a mobile phase composed of 25 mM phosphate buffer (pH = 5): methanol: acetonitrile (30:60:10, v/v/v)

ISSN: 2661-801X