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Table 4 Statistical comparison of the results obtained by the proposed spectrophotometric methods and reference method for the determination of PAR, PSE and CET

From: Analysis of paracetamol, pseudoephedrine and cetirizine in Allercet Cold® capsules using spectrophotometric techniques

Parameter PAR PSE CET
RSDM SDR DRZC PCCA Reference method RSDM SDR DRZC PCCA Reference method RSDM SDR DRZC PCCA Reference method
Mean 99.72 100.1 99.80 100.7 99.40 100.3 100.2 99.39 99.92 100.1 100.1 99.82 99.97 100.1 100.0
SD 0.5870 0.6200 0.9230 1.384 0.7780 0.8050 0.7310 1.130 1.110 0.4270 0.5720 0.5290 0.4290 0.5390 0.2340
N 6 6 6 6 4 6 6 7 6 4 6 6 6 6 4
Variance 0.3450 0.3840 0.8520 1.915 0.6050 0.6480 0.5340 1.277 1.232 0.1820 0.3270 0.2800 0.1840 0.2910 0.05500
Student’s t 0.7570 (2.310) 1.540 (2.310) 0.7130 (2.310) 1.660 (2.310)   0.3310 (2.310) 0.9290 (2.310) 1.200 (2.260) 2.070 (2.310)   0.2380 (2.310) 0.6830 (2.310) 0.2100 (2.310) 0.1290 (2.310)  
F 1.760 (5.410) 1.580 (5.410) 1.410 (9.010) 3.170 (9.010) 3.560 (9.010) 2.930 (9.010) 7.020 (8.940) 6.770 (9.010) 5.950 (9.010) 5.090 (9.010) 3.350 (9.010) 5.280 (9.010)
  1. Figures between parentheses represent the corresponding tabulated values of t and F at P = 0.05
  2. The reported method is an HPLC method using C18 column, a mobile phase composed of 25 mM phosphate buffer (pH = 5): methanol: acetonitrile (30:60:10, v/v/v)