Table 4 Lethal dose (in mg/kg) and percent inhibition of enzymes in Mycobacterium H37Rv groups after treatment with effective dose of 1.34 mg/kg of potent compounds and 25 µg/kg of positive control
Potent compounds | LD50 dose (mg/kg) | Percent inhibition of enzyme | ||
|---|---|---|---|---|
M. ICL activity (IU/L) | M. PS activity (IU/L) | M. CM activity (IU/L) | ||
1 | 1.83 | 62.21 | 56.34 | 48.32 |
2 | 1.81 | 58.78 | 50.13 | 48.56 |
3 | 1.87 | 52.56 | 47.56 | 42.24 |
4 | 1.96 | 48.45 | 38.45 | 31.78 |
6 | 1.86 | 56.78 | 50.65 | 48.23 |
8 | 1.88 | 59.45 | 42.21 | 37.45 |
10 | 1.83 | 61.23 | 54.32 | 42.23 |
12 | 1.85 | 43.45 | 36.45 | 28.76 |
13 | 2.14 | 56.45 | 54.12 | 40.23 |
15 | 2.67 | 61.56 | 56.34 | 40.34 |
17 | 3.17 | 43.45 | 36.45 | 28.76 |
18 | 3.15 | 64.56 | 60.12 | 58.23 |
Negative control | – | No reduction | No reduction | No reduction |
Streptomycin sulphate | – | 75.12 | 77.06 | 79.56 |