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Table 4 Lethal dose (in mg/kg) and percent inhibition of enzymes in Mycobacterium H37Rv groups after treatment with effective dose of 1.34 mg/kg of potent compounds and 25 µg/kg of positive control

From: Synthesis and evaluation of antimicrobial, antitubercular and anticancer activities of 2-(1-benzoyl-1H-benzo[d]imidazol-2-ylthio)-N-substituted acetamides

Potent compounds LD50 dose (mg/kg) Percent inhibition of enzyme
M. ICL activity (IU/L) M. PS activity (IU/L) M. CM activity (IU/L)
1 1.83 62.21 56.34 48.32
2 1.81 58.78 50.13 48.56
3 1.87 52.56 47.56 42.24
4 1.96 48.45 38.45 31.78
6 1.86 56.78 50.65 48.23
8 1.88 59.45 42.21 37.45
10 1.83 61.23 54.32 42.23
12 1.85 43.45 36.45 28.76
13 2.14 56.45 54.12 40.23
15 2.67 61.56 56.34 40.34
17 3.17 43.45 36.45 28.76
18 3.15 64.56 60.12 58.23
Negative control No reduction No reduction No reduction
Streptomycin sulphate 75.12 77.06 79.56