Fig. 5
Superposition of the poses of compounds 1 (yellow), 4 (magenta), and 5 (cyan) against putative halogen binding pocket interaction spheres for 5-HT7 (a) and 5-HT1A (b) receptors, respectively. The chlorine–oxygen theoretical interaction spheres illustrate the projected qualities of the formed ligand–receptor halogen bonds. The applied methodology is described by Wilcken et al. [33]