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Table 1 Conditions optimization for conversion of dioxacetal to O,P-acetal (2a)

From: Facile synthesis of α-alkoxymethyltriphenylphosphonium iodides: new application of PPh3/I2

Entry Solvent Time (h) Temperature (°C) Yield (%)
1 Toluene 01 80 27
2 Toluene 03 80 33
3 Toluene 03 Room temp 55
4 a Toluene 05 Room temp 80
5 Toluene 06 Room temp 69
6 02 Room temp 35
7 Acetonitrile 04 40 17
8 Acetonitrile 02 80 Traces
  1. aBest optimized conditions