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Table 2 Antimicrobial activities of the newly synthesized compounds

From: Microwave assisted synthesis of some new thiazolopyrimidine and pyrimidothiazolopyrimidopyrimidine derivatives with potential antimicrobial activity

Compound no.

IZ* ± SD**

Gram-negative

Gram-positive

Fungi

Yeast

E. coli

P. putida

B. subtilis

S. lactis

A. niger

P. sp.

C. albicans

1a

14 ± 0.58

10 ± 0.20

7 ± 0.29

8 ± 0.50

5 ± 0.29

5 ± 0.15

0

1b

12 ± 0.50

9 ± 0.15

6 ± 0.58

7 ± 0.29

4 ± 0.12

2 ± 0.20

0

1c

6 ± 0.29

3 ± 0.29

0

0

2 ± 0.15

2 ± 0.12

0

1d

3 ± 0.15

2 ± 0.20

0

0

0

0

0

3a

15 ± 0.58

11 ± 0.12

9 ± 0.50

6 ± 0.15

7 ± 0.58

5 ± 0.12

0

3b

12 ± 0.15

7 ± 0.29

7 ± 0.12

5 ± 0.50

7 ± 0.20

5 ± 0.50

0

3c

0

0

0

0

0

0

0

3d

3 ± 0.29

2 ± 0.20

0

0

0

0

0

5a

1 ± 0.20

0

7 ± 0.29

8 ± 0.29

6 ± 0.20

4 ± 0.29

3 ± 0.29

5b

1 ± 0.12

3 ± 0.15

7 ± 0.58

8 ± 0.20

6 ± 0.12

5 ± 0.15

3 ± 0.20

6a

1 ± 0.29

0

6 ± 0.12

8 ± 0.15

6 ± 0.20

4 ± 0.15

3 ± 0.15

6b

1 ± 0.12

2 ± 0.20

7 ± 0.20

8 ± 0.20

6 ± 0.15

4 ± 0.29

4 ± 0.12

8

14 ± 0.58

12 ± 0.50

7 ± 0.50

7 ± 0.12

6 ± 0.58

5 ± 0.29

2 ± 0.29

9a

15 ± 0.58

13 ± 0.15

8 ± 0.15

7 ± 0.29

7 ± 0.50

4 ± 0.12

2 ± 0.50

9b

10 ± 0.15

7 ± 0.29

6 ± 0.20

5 ± 0.29

2 ± 0.12

2 ± 0.20

0

10

16 ± 0.76

12 ± 0.15

9 ± 0.12

8 ± 0.58

5 ± 0.29

4 ± 0.29

3 ± 0.12

11

6 ± 0.20

3 ± 0.15

2 ± 0.29

0

2 ± 0.12

0

0

Chloramphenicol

22

21

18

19

1

0

0

Ampicillin

24

20

19

22

0

0

0

  1. *inhibition diameter zones expressed in millimeters (mm); ** standard deviation; E. coli, Escherichia coli; P. putida, Pseudomonas putida; B. subtilis, Bacillus subtilis; S. lactis, Streptococcus lactis; A. niger, Aspergillus niger; P. sp., Penicillium sp.; C. albicans, Candida albicans
  2. The sensitivity of microorganisms to the tested compounds is identified in the following manner: highly sensitive = inhibition zone: 15–20 mm; moderately sensitive = inhibition zone: 10–15 mm; slightly sensitive = inhibition zone: 1–10 mm; not sensitive = inhibition zone: 0 mm; each result represents the average of triplicate readings