Skip to main content

Advertisement

Table 2 Antimicrobial activities of the newly synthesized compounds

From: Microwave assisted synthesis of some new thiazolopyrimidine and pyrimidothiazolopyrimidopyrimidine derivatives with potential antimicrobial activity

Compound no. IZ* ± SD**
Gram-negative Gram-positive Fungi Yeast
E. coli P. putida B. subtilis S. lactis A. niger P. sp. C. albicans
1a 14 ± 0.58 10 ± 0.20 7 ± 0.29 8 ± 0.50 5 ± 0.29 5 ± 0.15 0
1b 12 ± 0.50 9 ± 0.15 6 ± 0.58 7 ± 0.29 4 ± 0.12 2 ± 0.20 0
1c 6 ± 0.29 3 ± 0.29 0 0 2 ± 0.15 2 ± 0.12 0
1d 3 ± 0.15 2 ± 0.20 0 0 0 0 0
3a 15 ± 0.58 11 ± 0.12 9 ± 0.50 6 ± 0.15 7 ± 0.58 5 ± 0.12 0
3b 12 ± 0.15 7 ± 0.29 7 ± 0.12 5 ± 0.50 7 ± 0.20 5 ± 0.50 0
3c 0 0 0 0 0 0 0
3d 3 ± 0.29 2 ± 0.20 0 0 0 0 0
5a 1 ± 0.20 0 7 ± 0.29 8 ± 0.29 6 ± 0.20 4 ± 0.29 3 ± 0.29
5b 1 ± 0.12 3 ± 0.15 7 ± 0.58 8 ± 0.20 6 ± 0.12 5 ± 0.15 3 ± 0.20
6a 1 ± 0.29 0 6 ± 0.12 8 ± 0.15 6 ± 0.20 4 ± 0.15 3 ± 0.15
6b 1 ± 0.12 2 ± 0.20 7 ± 0.20 8 ± 0.20 6 ± 0.15 4 ± 0.29 4 ± 0.12
8 14 ± 0.58 12 ± 0.50 7 ± 0.50 7 ± 0.12 6 ± 0.58 5 ± 0.29 2 ± 0.29
9a 15 ± 0.58 13 ± 0.15 8 ± 0.15 7 ± 0.29 7 ± 0.50 4 ± 0.12 2 ± 0.50
9b 10 ± 0.15 7 ± 0.29 6 ± 0.20 5 ± 0.29 2 ± 0.12 2 ± 0.20 0
10 16 ± 0.76 12 ± 0.15 9 ± 0.12 8 ± 0.58 5 ± 0.29 4 ± 0.29 3 ± 0.12
11 6 ± 0.20 3 ± 0.15 2 ± 0.29 0 2 ± 0.12 0 0
Chloramphenicol 22 21 18 19 1 0 0
Ampicillin 24 20 19 22 0 0 0
  1. *inhibition diameter zones expressed in millimeters (mm); ** standard deviation; E. coli, Escherichia coli; P. putida, Pseudomonas putida; B. subtilis, Bacillus subtilis; S. lactis, Streptococcus lactis; A. niger, Aspergillus niger; P. sp., Penicillium sp.; C. albicans, Candida albicans
  2. The sensitivity of microorganisms to the tested compounds is identified in the following manner: highly sensitive = inhibition zone: 15–20 mm; moderately sensitive = inhibition zone: 10–15 mm; slightly sensitive = inhibition zone: 1–10 mm; not sensitive = inhibition zone: 0 mm; each result represents the average of triplicate readings