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Table 3 Cytotoxicity of compounds 15, 16, 17, 18, 19, 20 and Doxorubicin against hepatocellular carcinoma cell line HePG2

From: Design, synthesis and evaluation of anticancer activity of novel 2-thioxoimidazolidin-4-one derivatives bearing pyrazole, triazole and benzoxazole moieties

Concentration µg/mL

Viability (%)/compound

15

16

17

18

19

20

Doxorubicin

500

6.49

4.31

6.78

4.68

3.84

6.91

3.6

250

11.25

11.72

15.93

10.35

9.65

11.76

3.97

125

19.43

18.25

24.85

17.46

13.81

20.95

6.43

62.5

30.61

23.87

34.91

25.72

19.46

32.47

9.68

31.25

39.45

30.64

42.87

32.69

25.83

44.35

16.45

15.6

51.26

38.92

67.29

44.82

32.17

76.97

23.87

7.8

67.18

47.30

83.97

51.96

39.68

89.50

30.69

3.9

84.91

64.59

91.48

64.53

48.54

94.16

37.54

2

92.73

76.28

98.02

72.31

61.83

98.73

42.91

1

96.48

81.49

100

79.48

69.42

100

48.76

0

100

100

100

100

100

100

100