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Table 2 Intra- and inter-day precision and accuracy of quality control sample

From: Development and validation of an HPLC–MS/MS method for the determination of arginine-vasopressin receptor blocker conivaptan in human plasma and rat liver microsomes: application to a metabolic stability study

Parameter

Human plasma

RLMs

LQC (15 ng)

MQC (150 ng)

HQC (400 ng)

LQC (15 ng)

MQC (150 ng)

HQC (400 ng)

 

Intra-day

Mean

14.75

147.11

392.75

15.01

149.65

399.54

SD

0.47

2.34

6.22

0.43

1.91

5.16

RSD (%)

3.18

1.59

1.58

2.90

1.28

1.29

RE (%)

− 1.64

− 1.93

− 1.81

0.05

− 0.23

− 0.12

 

Inter-day

Mean

14.74

146.99

392.28

14.98

149.40

398.72

SD

0.44

2.82

7.36

0.37

2.20

5.90

RSD (%)

3.01

1.92

1.88

2.49

1.47

1.48

RE (%)

− 1.74

− 2.01

− 1.93

99.86

99.60

99.68

Accuracy

98.26

97.99

98.07

− 0.14

− 0.40

− 0.32