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Table 2 Intra- and inter-day precision and accuracy of quality control sample

From: Development and validation of an HPLC–MS/MS method for the determination of arginine-vasopressin receptor blocker conivaptan in human plasma and rat liver microsomes: application to a metabolic stability study

Parameter Human plasma RLMs
LQC (15 ng) MQC (150 ng) HQC (400 ng) LQC (15 ng) MQC (150 ng) HQC (400 ng)
  Intra-day
Mean 14.75 147.11 392.75 15.01 149.65 399.54
SD 0.47 2.34 6.22 0.43 1.91 5.16
RSD (%) 3.18 1.59 1.58 2.90 1.28 1.29
RE (%) − 1.64 − 1.93 − 1.81 0.05 − 0.23 − 0.12
  Inter-day
Mean 14.74 146.99 392.28 14.98 149.40 398.72
SD 0.44 2.82 7.36 0.37 2.20 5.90
RSD (%) 3.01 1.92 1.88 2.49 1.47 1.48
RE (%) − 1.74 − 2.01 − 1.93 99.86 99.60 99.68
Accuracy 98.26 97.99 98.07 − 0.14 − 0.40 − 0.32