Skip to main content

Advertisement

Table 42 In vivo anti-inflammatory activity

From: Therapeutic potential of heterocyclic pyrimidine scaffolds

Compounds Oedema induced by carrageenan (% oedema % inhibition relative to control)
1 h 2 h 3 h 4 h
Swel % inh Swel % inh Swel % inh Swel % inh
e21 0.206 10.43 0.101 61.15 0.142c 73.9 0.132b 79.04
e22 0.196 14.78 0.182 30 0.022c 95.58 0.282 67.43
e23 0.216 6.08 0.012b 95.38 0.024c 95.95 0.202a 76.82
Ibuprofen 0.216 6.08 0.14 45 0.214b 60.66 0.192a 69.52
  1. As indicated: a P < 0.05; b P < 0.01; c P < 0.001