Therapeutic potential of heterocyclic pyrimidine scaffolds

BMC Chemistry

Table 42 In vivo anti-inflammatory activity

Compounds	Oedema induced by carrageenan (% oedema % inhibition relative to control)
	1 h		2 h		3 h		4 h
	Swel	% inh	Swel	% inh	Swel	% inh	Swel	% inh
e21	0.206	10.43	0.101	61.15	0.142^c	73.9	0.132^b	79.04
e22	0.196	14.78	0.182	30	0.022^c	95.58	0.282	67.43
e23	0.216	6.08	0.012^b	95.38	0.024^c	95.95	0.202^a	76.82
Ibuprofen	0.216	6.08	0.14	45	0.214^b	60.66	0.192^a	69.52

ISSN: 2661-801X